Pregnancy Risk Category B
How supplied
Tablets: 250 mg
Action
Inhibits squalene epoxidase, a key enzyme in sterol biosynthesis of fungi. This enzyme inhibition results in a deficiency of ergosterol and a corresponding accumulation of sterol within the fungal cell.
Indications & dosage
Fingernail onychomycosis due to dermatophytes (tinea unguium)-
Adults: 250 mg P.O. once daily for 6 weeks.
Toenail onychomycosis due to dermatophytes (tinea unguium)-
Adults: 250 mg P.O. once daily for 12 weeks.
Adverse reactions
CNS: headache.
EENT: taste disturbances, visual disturbances.
GI: diarrhea, dyspepsia, abdominal pain, nausea, flatulence.
Hepatic: hepatobiliary dysfunction (including cholestatic jaundice).
Hematologic: neutropenia, decrease in absolute lymphocyte counts.
Skin: rash, pruritus, urticaria, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Other: hypersensitivity reactions, anaphylaxis.
Interactions
Drug-drug. Cimetidine: decreases drug clearance by one-third. Avoid concomitant use.
Cyclosporine: drug increases clearance of cyclosporine. Monitor serum levels.
Rifampin: increases terbinafine clearance by 100%. Monitor patient.
Drug-food. Caffeine: I.V. caffeine clearance is decreased. Use cautiously
together.
Effects on diagnostic tests
None reported.
Contraindications
Contraindicated in patients with hypersensitivity to drug.
Nursing considerations
Patient teaching
*Liquid contains alcohol. **May contain tartrazine. †Canada ‡Australia §U.K. OTCOver the counter
Reactions may be common, uncommon, life-threatening, or COMMON AND LIFE-THREATENING