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mupirocin
Bactroban, Bactroban Cream, Bactroban Nasal

Pregnancy Risk Category B

How supplied
Topical ointment:
2%
Topical cream:
2%
Intranasal ointment:
2%

Action
Unknown. Thought to inhibit bacterial protein and RNA synthesis.

Indications & dosage
Impetigo-
-
Adults and children:
apply to affected areas t.i.d. for 1 to 2 weeks. Reevaluate patient in 3 to 5 days; may cover affected area with dressing.
Secondarily infected traumatic skin lesions due to
Staphylococcus aureus and Streptococcus pyogenes--
Adults and children:
apply thin film t.i.d. for 10 days; may cover with gauze dressing, if needed. Reevaluate patient if clinical improvement doesn't occur in 3 to 5 days.
Eradication of nasal colonization with methicillin-resistant
S. aureus in adult patients and health care workers--
Adults and children ages 12 and older:
divide ointment in single-use tube between nostrils (1/2 tube per nostril) b.i.d. for 5 days. After application, close nostrils by pressing together and releasing sides of nose repeatedly for 1 minute to spread ointment throughout nares.

Adverse reactions
CNS:
headache.
EENT:
rhinitis, pharyngitis, taste perversion, burning or stinging with intranasal use.
Respiratory:
upper respiratory tract congestion, cough with intranasal use.
Skin:
burning, pruritus, stinging, rash, pain, erythema with topical use.

Interactions
None significant.

Effects on diagnostic tests
None reported.

Contraindications
Contraindicated in patients with hypersensitivity to drug or its components.

Nursing considerations

Patient teaching

*Liquid contains alcohol. **May contain tartrazine.  †Canada  ‡Australia  §U.K.  OTCOver the counter
Reactions may be common, uncommon, life-threatening, or COMMON AND LIFE-THREATENING

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