Pregnancy Risk Category C
How supplied
Tablets: 500 mg, 750 mg
Action
Unknown. Probably acts by inhibiting prostaglandin synthesis.
Indications & dosage
Rheumatoid arthritis, osteoarthritis--
Adults: initially, 1,000 mg P.O. daily as a single dose or in divided doses b.i.d. Maximum daily dose is 2,000 mg.
Adverse reactions
CNS: dizziness, headache, fatigue, insomnia, nervousness, somnolence.
CV: vasculitis, edema.
EENT: tinnitus.
GI: diarrhea, dyspepsia, abdominal pain, constipation, flatulence, nausea, dry mouth, gastritis, stomatitis, anorexia, vomiting, bleeding, ulceration.
Respiratory: dyspnea, pneumonitis.
Skin: pruritus, rash, increased diaphoresis.
Interactions
Drug-drug. Diuretics: NSAIDs may decrease diuretic effectiveness. Monitor patients closely during therapy.
Warfarin, other highly protein-bound drugs,: increased risk of adverse effects from displacement of drugs by nabumetone. Use together cautiously.
Drug-food. Any food: increased absorption. Give drug with food.
Drug-lifestyle. Alcohol use: associated with an increased risk of additive GI toxicity. Avoid concomitant use.
Effects on diagnostic tests
None reported.
Contraindications
Contraindicated in patients with hypersensitivity reactions and history of aspirin- or NSAID-induced asthma, urticaria, or other allergic-type reactions.
Nursing considerations
Patient teaching
*Liquid contains alcohol. **May contain tartrazine. †Canada ‡Australia §U.K. OTCOver the counter
Reactions may be common, uncommon, life-threatening, or COMMON AND LIFE-THREATENING