Pregnancy Risk Category C
How supplied
Capsules: 200 mg, 300 mg
Tablets: 400 mg, 500 mg
Tablets (extended-release): 400 mg, 500 mg, 600 mg
Action
Unknown. Possibly related to inhibition of prostaglandin biosynthesis.
Indications & dosage
Acute pain--
Adults: 200 to 400 mg P.O. q 6 to 8 hours, p.r.n., not to exceed 1,200 mg daily. In patients weighing 60 kg (132 lb) or less, don't exceed total daily dose of 20 mg/kg.
Acute and chronic management of osteoarthritis and rheumatoid arthritis--
Adults: 600 to 1,000 mg P.O. daily, divided into two or three doses. Maximum dose is 1,200 mg/day. For extended-release product, 400 to 1,000 mg P.O. daily. Maximum dose is 1,000 mg/day.
Adverse reactions
CNS: asthenia, malaise, dizziness, depression, drowsiness, nervousness, insomnia, syncope.
CV: hypertension, heart failure, flushing, palpitations, edema, fluid retention.
EENT: blurred vision, tinnitus, photophobia.
GI: dyspepsia, flatulence, abdominal pain, diarrhea, nausea, constipation, gastritis, melena, vomiting, anorexia, peptic ulceration with or without GI bleeding or perforation, ulcerative stomatitis, thirst, dry mouth.
GU: dysuria, urinary frequency, renal failure.
Hematologic: anemia (rare), leukopenia, hemolytic anemia.
Hepatic: hepatitis.
Metabolic: weight gain.
Respiratory: asthma.
Skin: pruritus, rash, Stevens-Johnson syndrome.
Other: chills, fever.
Interactions
Drug-drug. Antacids: may decrease peak levels of drug. Monitor for decreased effect of etodolac.
Aspirin: reduced protein-binding of etodolac without altering its clearance. Clinical significance unknown. May increase GI toxicity. Avoid concomitant use.
Beta blockers, diuretics: effects may be blunted. Monitor closely.
Cyclosporine: impaired elimination and increased risk of nephrotoxicity. Avoid concomitant use.
Digoxin, lithium, methotrexate: etodolac may impair elimination of these drugs, resulting in increased levels and risk of toxicity. Monitor blood levels.
Phenytoin: increased serum levels of phenytoin. Monitor for toxicity.
Warfarin: etodolac decreases the protein-binding of warfarin but doesn't change its clearance. Although no dosage adjustment is needed, monitor INR closely and watch for bleeding.
Drug-lifestyle. Alcohol use: increased chance of adverse effects. Avoid use.
Sun exposure: photosensitivity reactions may occur; take precautions.
Effects on diagnostic tests
A false-positive test for urinary bilirubin may be caused by phenolic metabolites.
Contraindications
Contraindicated in patients with hypersensitivity to drug and in those with history of aspirin- or NSAID-induced asthma, rhinitis, urticaria, or other allergic reactions.
Nursing considerations
Patient teaching
*Liquid contains alcohol. **May contain tartrazine. †Canada ‡Australia §U.K. OTCOver the counter
Reactions may be common, uncommon, life-threatening, or COMMON AND LIFE-THREATENING