Pregnancy Risk Category B
How supplied
Tablets: 10 mg
Action
Unknown. Relieves skeletal muscle spasm of local origin without interfering with muscle function.
Indications & dosage
Short-term treatment of muscle spasm--
Adults: 10 mg P.O. t.i.d. Maximum daily dose is 60 mg; maximum duration of treatment is 2 to 3 weeks.
Adverse reactions
CNS: drowsiness, headache, insomnia, fatigue, asthenia, nervousness, confusion, paresthesia, dizziness, depression, seizures, dysarthria, ataxia, syncope.
CV: tachycardia, arrhythmias, palpitations, hypotension, vasodilation.
EENT: blurred vision, visual disturbances.
GI: dyspepsia, abnormal taste, constipation, dry mouth, nausea.
GU: urine retention, urinary frequency.
Skin: rash, urticaria, pruritus.
Other: with high doses, adverse reactions similar to those of other tricyclic antidepressants.
Interactions
Drug-drug. Anticholinergics: additive anticholinergic effects. Avoid concomitant use.
CNS depressants: increased CNS depression. Avoid concomitant use.
MAO inhibitors: Hyperpyretic crisis, seizures and death have occurred with concomitant administration of MAO inhibitors and tricyclics; the potential for this interaction with cyclobenzaprine also exists. Don't give within 14 days after discontinuing MAO inhibitors.
Drug-lifestyle. Alcohol use: increased CNS depression. Avoid concomitant use.
Effects on diagnostic tests
None reported.
Contraindications
Contraindicated in patients with hypersensitivity to drug and in those with hyperthyroidism, heart block, arrhythmias, conduction disturbances, or heart failure; also contraindicated in those who have received MAO inhibitors within 14 days or who are in the acute recovery phase of an MI.
Nursing considerations
Patient teaching
*Liquid contains alcohol. **May contain tartrazine. †Canada ‡Australia §U.K. OTCOver the counter
Reactions may be common, uncommon, life-threatening, or COMMON AND LIFE-THREATENING